Agomelatine|Octadecanedioic acid monotert butyl ester|Fmoc-Lys(tBu-OOC-C16-CO-Glu(AEEA-AEEA)-OtBu)-OH|Ghk Cu|Intermediate of Lucitinib and Barecitinib--Allsino Pharmaceutical Co., Ltd.

Customized Services

Business Scope :

Providing R&D and production of RSMs & API for global pharmaceutical companies

Professional research institute

80 scientists with professional background and experience providing process R&D from route design, optimization to full CMC support and chemical synthetic solutions such as chiral synthesis, heterocycle chemistry, continuous flow chemistry and photochemistry with comprehensive analytic instruments (HPLC, LCMS, HRMS, NMR, RM, ICP-MS, TGA, Marvin granulometer, ICS etc.) and Safety & Risk assessment laboratory (Mettler DCS, Mettler RC 1e, THT ARC)

Massive production Plant

6 chemical synthesis workshops, 1 hydrogenation workshop, and 5 API GMP workshops (2 under construction); 326 reactors including 33pcs 10000L , 101pcs 5000L , 65pcs 3000L, 2 Hastelloy reactors.

EHS Infrastructure

covering an area of 16,500m2 including a 500 mt/d waste-water treatment station, 2 waste gas incinerators（RTO）, 1 waste liquid incinerator (VR) and DCS&SIS

CDMO / CMO of small molecular chemical API and intermediates

The CDMO project of the company is led by Dr. Guoqiang Shi, a national high-level talent and a “Thousand Talents in Zhejiang Province”, responsible for high value-added projects with high technical requirements and difficult process development. After years of accumulation, the company has the ability to undertake various CDMO projects with high technology content, and the main techniques and capabilities are as follows:

Hydrogenation reaction: hydrogenation reactors (including Hastelloy alloy) with a capacity of 300 to 6,000 liters and a pressure of 100 ATM;
Ammoniation reaction: maximum of 10,000 liters of liquid ammonia ammoniation reactor, liquid ammonia storage license is issued.;
Nitrification, diazotization, azide and other reactions;
Ultra-low temperature reaction: maximum below -80℃, continuously controlled is below -60℃;
Metal catalytic reaction: highly active metal catalytic reaction technology;
Molecular distillation technology and equipment;
Chiral split technology;
Continuous flow microchannel green chemistry technology;
Photochemical reaction technology;
Safety control technology of ultra-high temperature reaction : up to 280℃;
Safety evaluation technology of chemical process : DSC, RC1, ARC and other safety evaluation facilities and technicians.